In Game 2, 17-game winner Carl Pavano started for the Twins, hoping to even the series. Pavano faced the Yankee veteran Andy Pettitte. Like in Game 1, the Twins struck first in the second inning when Delmon Young scored on a Danny Valencia sacrifice fly.
The Yankees tied the game in the top of the fourth inning, as Curtis Granderson doubled, advanced to third base on Mark Teixeira's single, then scored on Alex Rodriguez's sacrifice fly.
Designated hitter Lance Berkman homered in the fifth inning to take the lead for the Yankees. But Orlando Hudson tied it up with a solo homer in the bottom of the sixth inning.
In the top of the seventh inning, Berkman's RBI double over the head of the Twins center fielder Denard Span once again took the lead for the Yankees. Like Joe Maddon did earlier in the Rangers–Rays game, Twins manager Ron Gardenhire argued about the 1–2 borderline pitch right before Berkman's double and got ejected. Later Derek Jeter's RBI single scored Berkman and made the score 4–2.
Granderson's RBI single scored Brett Gardner in the top of the ninth inning. In the bottom of the ninth inning, Mariano Rivera gave up a leadoff single to Joe Mauer, but got Delmon Young to ground into a double play and then induced a fly ball to left field from Jim Thome for the second consecutive save in the series.
This was Andy Pettitte's 19th career postseason win and Mariano Rivera's 41st postseason save; both are all-time postseason pitching records. Also, this was the 11th straight postseason loss for the Twins and eighth straight postseason loss against the Yankees.